General description

A cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC₅₀ = 8 µM), as well as HL-60 (IC₅₀ = 5 µM) and K562 (IC₅₀ = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Su, J.C., et al. 2009, Life Sci.85, 505.Chien, C.M., et al. 2008, Chem-Biol. Intr.176, 40.Yang, S.H., et al. 2008, J. Biochem. Mol. Tox.22, 396.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)